I tried this product in my teenage years while I was having horrible breakouts. This product is compared to Proactive treatments. Well the both suck! If you miss one day of doing to 3 step process you start to break out! I believe it is just a marketing gimmick. Effectiveness Acne would come back if one day of application was missed. Ease of Application Wash with the AcneFree face wash. Apply a toner and then a cream. Easy but annoying. Convenience Three step process was just too much to do twice a day. Side Effects Did not experience any. Immediacy Did not experience any positive results.