Prilosec it the most effective I have found as of yet to help with heartburn. This can make a difference in your life if you are a sufferer of heartburn. I have tried many things but this is buy far the easiest and most effective I have found. I take it once a day and I never have to worry about heart burn. It does say on the package not to exceed 14 days. I know some who take it every single day and don't seem to have any side effects but myself I just take it when I know I will be eating something that will give me heartburn. So I don't recall ever taking it for more then 14 days in a row, now sure if there would be side effects if you did. It has been very effective for me using them in this manner. I have forgotten to take it, or have eating something unexpected that gave me heartburn and I hadn't taken one and took it once the heartburn hit and it would work in a matter of minutes to give me relief. I would say this is the next best thing to a prescription heart burn medication. These pills are tiny enough to be able to take anytime without water or causing gagging, there is no aftertaste from them either.