When depression reared its ugly face in the summer of 2006, I headed right for my doctor. I had been on antidepressents years before, and knew the symtoms. I started with the Zoloft and Prozac, but neither of these did it for me, not too mention the lack of sexual feelings you begin to get from them. So my doctor prescribed Wellbutrin for me. I really started feeling better within days. I did not get any negative side effects, but I was happy to start losing weight. In about 4 months I lost about 30 pounds. I am overweight to begin with, so this was a real boost to my moods. However, you do start gaining it back, and with it came about 10 additonal pounds. About 18 months later, I began losing weight again. I lost almost the same amount as last time, 35 pounds. Right now, I have gained 28 pounds back, and it is getting worse every week. I don't know the ryhme or reason behind the weight loss, but I do wish I would begin losing again. This medication is also prescribed for smoking cessation. It has caused my depression to abate, and I am pleased with this medication for that reason.