I have suffered from treatment resistant depression for 30 years and tried many things. I don't know how I missed Celexa. I was suicidal before I started taking it. I have been taking it for 6 weeks, and I feel wonderful. The first 3 weeks were MISERABLE. I was so exhausted and sedated that I might as well have been stoned. I could not drive. I couldn't do anything. I had almost given up hope that it could improve and then - BAM! - it did. I am on 20 mg now. I took 10 mg the first week, and then tried taking 10 mg twice a day until I could handle a full dose without crawling into bed and passing out. Now I take my 20 mg at 5 pm, and I am clear-headed during the day. It's worth hanging on and giving it a chance to work out! I pray it keeps working as well as it has.