I suffered from terrible morning-noon-and-night sickness throughout the first 5 months of my pregnancies. With my second pregnancy, my doctor prescribed Phenergan, which I quit taking after a few pills since it wasn't working. By my third pregnancy, a new drug called Zofran was available, so my doctor prescribed this. I was still hesitant to take drugs during pregnancy, but I was throwing up everything (even water) multiple times per day, so I thought I'd try it. In a sense, it was more effective than the Phenergan had been. I still felt constant nausea, but I didn't actually vomit as often. However, it did cause me to become terribly constipated for the first time in my entire life! It was a bad enough experience that I decided to quit taking Zofran. It wasn't worth the constipation, especially since I still felt awful. Also, I couldn't shake the feeling that the drug could possibly be affecting my baby (although my doctor assured me that it was about as safe any drug during pregnancy could be). The next few months weren't pleasant, but my baby and I made it through okay.