I had an imbalance in my brain chemistry and was prescribed anti-depressant medications. I was also having trouble sleeping, so my doctor prescribed Mirtzapine which is the generic for Remeron. Remeron is also used to treat depression. You will develop a tolerance to most prescription sleep medications over time if you use them regularly; but I seem to develop that tolerance very quickly. With some new medications that my doctor has prescribed, I received no benefit at all. The Mirtzapine's ability to help me relax and fall asleep was quickly reduced to -0- within two weeks even though I only took the medication sporadically. Each person reacts differently to each medication. If your doctor prescribes Remeron (Mirtzapine) for you, be sure to do two important things: Give him/her a complete list of any other medications or supplements that you are taking; and be sure to discuss any possible side effects. I do not endorse this medication in any way. Do not be swayed by my comments just because this medication does not work well for me...It might work very well for you!