Not only are they easy on my nose, but the designs of the cubes are great, too. In this season of sniffles and sneezes, tissues are a must and I choose to have Puffs around my apartment. They keep my nose from becoming irritated and red, which not only keeps soreness away, but helps my self-esteem while I am sneezing away, too!! :) Due to my sensitive sense of smell, I can't use the ones with Vicks in them and these are a great alternative. Of course, they cost a bit more than plain old tissue, but to me it is worth it because of the soothing results Puffs offers. Regular tissue is rough on my nose, actually REALLY rough and that is not pleasant at all. Puffs are VERY PLEASANT and I will continue to spend the extra money for them!