I started taking Plaquenil over a year ago for joint pain. When I first started taking it I was very disappointed. I had experienced no relief, however after a few weeks it really started to work and I finally got relief from my joint pain! My doctor told me that it was completely normal for Plaquenil to take awhile before fully working. I am very grateful that my doctor prescribed this for me, because before it my joints were extremely painful! I have not experienced any side effects while on Plaquenil. Plaquenil is also very affordable.