Huggies Supreme Baby Wipes are the "Cadillac" of baby wipe choices. They truly are indisputably the softest, thickest disposable baby wipes on the market. They're expensive and there are less wipes per box than other brands, and even other types of Huggies Wipes. If I could have afforded it, I would have used these every time when my kids were in diapers. That wasn't in the budget though honestly, and I ended up using other brands most of the time. I would usually spend the extra money for Huggies Supreme if my kids had a diaper rash or were sick. There also good in the very beginning for newborns since they get changed much more often and are more prone to irritation from less expensive wipes. Durability They're the thickest and softest disposable baby wipes out there. Nothing else compares really. I've never had one tear. Performance You can clean a mess with one Huggies Supreme Wipe that would take three or four store brand wipes.