Deplin is special as its by prescription only, but is also actually a synthetic supplement (a form of folate that can pass the blood brain barrier) which makes it more natural and yet a little more expensive at the same time depending upon your prescription drug coverage. It builds up in your system over time, as many depression medications do, and honestly its hard to tell if it makes a huge difference but when I run out and go off of it, I always think to myself- it really did make a difference! And so I go and refill it and resume taking it...(sound familiar??) It turns out that there is a genetic mutation in the enzyme which converts folate that you eat into the form of folate(I forget the chemical break down name) that is able to get to your brain; your doctor/psychiatrist can actually do bloodwork which determines whether you have this mutation or not. Depending upon your results, you can know for sure that about only 30% of the folate you intake actually gets to your brain! Finding out I had this mutation did motivate me to take this medication/supplement in addition to my Cymbalta.