Just ask one of my dogs, we live in the deep woods, and fleas and ticks are a major major problem. We rely on Certifect, from the maker's of frontline, to keep our dogs flea and tick free. This one is for 23 to 44 lb weight size dogs. Comes 3 tubes to a box, unless you find somewhere that sells it by the tube. Give yourself and your dogs the benefit of Certifect year round for protection, and stay rid of fleas and ticks in your home. Quality of Ingredients Here in the deep woods, we rely on Certifect for our dogs. Side Effects none , except on collie breeds, do not use on collie's, blue heelers, etc.