Love the Tempurpedic mattress.  Had the worst pain in lower back and while it took about a week for the pain to completely subside, it hasn't been back since.  The spring mattress I used to have did not support me in the right spots. 

Highly recommend; only con is the price tag.  Another alternative (slept on friend's) is the Bodipedic bed from QVC -- it felt pretty similar to my Tempurpedic for a fraction of the cost.