This definitely helped reduce the spit up. We started out on Nestle GoodStart and she was constantly spitting up - it got to the point where it was coming out of her nose so we tried this and it worked a lot better than I had expected. When we first switched I did notice a difference in poop, but she wasn't having any problems with it. It is difficult to get all the lumps out when using the powder though, but the Nestle wasn't much better. If you're having spit up problems I would definitely try this.