I have been taking Zoloft for 3 years now and it has completely stabilized the depressive phase of my bi-polar. I am on a relatively small dose of Zoloft (25 mg/daily) and, in combination with other drugs, it has eliminated most of my depressive phases. My mother also began taking Zoloft for depression based on my success with the medicine. Zoloft has also been helpful for her. I have not noticed any side affects in the three years I have been taking Zoloft. I would recommend speaking with your doctor about the possibility of Zoloft helping you as well.