Zoloft has been an absolute lifesaver for me.  I have been on the medication about 10 years.  Before starting Zoloft - every little thing got under my skin and made me mad.  I had no patience for my children, and when I lost my temper I would be screaming at the top of my lungs.  They started me off on the lower doses of the medicine (25 mg.) but over time the dosage has increased to 200 mg. a day.  That may seem like a lot, but I'm a different person when taking the medicine - don't argue my point, more patience for my kids.  When my husband or kids start to argue with me, instead of trying...