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I am a wimpy cold sufferer. I hate having to blow my nose and wipe my nose. Of all the tissues I have tried, by far Puffs Plus with lotion is THE BEST tissue. They do not leave my nose red or sore. You cannot use them to clean off your glasses, though. They will leave your glasses with a residue ... but that is not what they're for. It does keep my nose from that dryness and soreness from the constant wipe. I have not tried the kind with the Vicks yet. That will be my next cold!