2009 VIP
Jo
Plymouth, MA
Our health care system can make anyone depressed
4 star rating

safety conscious, fun loving, have Sjogren's Syndrome, believe in universal health care, taking meds to control anxiety
Pros

    it works, no side effects

Cons
    the generic may not be the same

OCT
22
2007
 
 

Wellbutrin Bupropion Hydrochloride — 

To the Point

I take Wellbutrin - actually I take the generic version called bupropion. There are several strengths and types. I take the ER (extended release which is the same as the timed release) form. It is taken for depression. Although I am not depressed when my doctor put me on clonazepam (generic name)/ Klonopin (brand name) (reviewed) for anxiety he put me on Wellbutrin to counter-act the possible symptom of depression that Klonopin causes.

Bupropion sometimes is given to help people stop smoking. Although how this drug works is not clear it's thought that it changes the concentration of some chemicals that are needed for nerve transmission in the brain. I take the smallest dose which is 150 mg.

The side affects include constipation, decreased appetite, diarrhea, dizziness, dry mouth, headache, and insomnia. These may subside after your body gets used to it. I have no side affects that I know of from this drug. I do have dry mouth but I have an autoimmune disorder which causes it. I have taken Wellbutrin (bupropion) for a much longer time than I've had Sjogren's Syndrome.

This may all informative but the purpose of this review is to make people aware that in studies done by The ConsumerLab www.consumerlab.com/results/wellbutrin-bupropion.asp the generic drug, bupropion, worked differently than the non-generic drug Wellbutrin XL. Time-released generic drugs they found sometimes use tablet technologies that differ from the original product. When I brought this study to my doctor he suggested that the tablet coating itself can be different. However he also mentioned the cost of the non-generic drug i.e. health insurers prefer doctors to prescribe generics. There are along with the study anecdotal stories by consumers of symptoms they had when they were switched to the generic drug. Reports of generic drug problems by consumers are posted at ww.peoplespharmacy.com.

Interestingly the FDA doesn't require that generic brands get approval for clinical trials like they do for brand name drugs. The tests on brand name drugs require hundreds if not thousands of people in the test. The agency requires that generic drugs be tested so that there is lab data in three dozen or fewer people that show the drug in the bloodstream seeming to act in a similar way as the brand name.

Jo's Viewpoint

I am fine with the generic formula. It hasn't caused me any problems. I do believe that people should be aware of these substantiated problems with some generic drugs. I don't believe Wellbutrin is the only drug that is affected by the use of the generic formula.



I_thumb_up Wellbutrin Bupropion Hydrochloride is recommended by Jo

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I_comment_shdw24 Comments about Jo’s Review

 


Spady wrote on Feb 4, 2009 at 4:47PM

Very informative, researched, interesting AND well written...from a retired teacher.

Novegon wrote on Apr 7, 2008 at 12:11PM

I too have had problems with the generic equivalent to my Wellbutrin. This too the point that I will no longer allow a generic substitution. Its just not worth my mental health. :-)

Meredith wrote on Oct 23, 2007 at 7:10AM

I agree with the comment from Kristy about why the Doc automatically assumed you would experience depression as a side affect without even waiting to see what happened. I think there are serious cases of over-prescribing here in the US. But I am so glad Wellbutrin is helping you as it has so many other people I know personally :) Great review Jo.

PattyTherre wrote on Oct 22, 2007 at 10:23PM

My doctor once mentioned this drug to me because I get Seasonal Affective Disorder but it causes anxiety and I am a walking ball of anxiety plus it could cause seizures in some people. My son had a severe seizure disorder when he was young and I have no idea if I have a lower tolerance to seizures so I flatly refused. As for generic vs name brand, my doctor will only give me name brand and, if he doesn't, I initial the box myself. Costs me more in copays but I'm worth it.

CyndiA wrote on Oct 22, 2007 at 8:26PM

I never take ANYTHING without doing my own research. Good for you for checking. Join the non-compliant patient list. If a doc can't handle that, find another I say.

Kristy wrote on Oct 22, 2007 at 8:09PM

It's odd he would put you on it before he waited to see IF you got depressed as a side effect. I would think not everyone would automatically be depressed - does that make sense?
I'm glad it is working for you :-)