Within minutes of application our Bichon and love of our life Clayton went crazy, running and jumping and ended up with what appeared to be seizures and had to be rushed to Vet. After shot appeared better only to get worse. Have reported to Vet and manufactuer. They are required to notify the EPA. Do not use, we thought we would lose our beloved dog. We successfully used frontline for 7 years and switched when Vet recommeded Vectra. Caution, read what this contains. Scary!