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I was on seroquel for about a year for "bi polar disorder" later re-diagnosed as "schizophrenia" later rediagnosed for "schizoaffective" I have been on a lot of medication for things like this and so far seroquel is the only thing that has been successful. Given individual results are totally different- i had no problem with weight gain or any other side effects EXCEPT sleepyness. it is IMPOSSIBLE to wake up, you're tired all day, and eventually i went off of it because i couldnt stay awake in order to enjoy my life without the affects of my disorder. so what was the point? Dont get me wrong-when it comes to managing symptoms-its awesome. When it comes to tolerability-it just wasnt for me. Even after a mega amount of b vitamins and coffee-nothing.