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I have suffered from migraines for many years, and been on several different medications for them. I was on Imitrex for quite a bit of that time, and then it started not working for me. I would get "rebound" headaches a few hours or later in the day after I took the medication. At that time I was still working as a nurse, so this was not something that was good for me, so my neurologist started me on Relpax. It is the same type of medicine as Imitrex, but works better for me. It maybe takes a little bit longer to start working (maybe anywhere from 30min.-1 hour, depending on how soon I take one when I feel the headache coming on), but the headaches do not come back, so to me that is better. And, I do not feel any chest pain or tightness like I usually did with Imitrex.
So, for me, Relpax has been a much better choice to help when I get a migraine.