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i have a pain disorder called RSD. it basically causes 24/7 pain. on the mc gills pain scale the pain associated with RSD is worse then any other pain including child birth and having a limb amputated. i have tried just about ever pain medicine out there with no pain relief. my doctor suggested opana er. i kind of brushed it off and assumed it wouldn't work. to my surprise i took the medicine and about 1/2 an hour lated i had very little pain. it was so amazing and i was so thankful my doctor suggested it. i now suggest it to anyone with chronic pain. its an amazing drug although i know not all drugs work the same for everyone most people i have spoken too on opana have had good luck.