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My daughter is mostly breast fed until 6 months old. When we started supplimenting formula, we had tons of samples & coupons from all 3 major brands, i.e. Enfamil, Similac, & Nestle, so we tried most of them. My daughter is ok with all those formulas, virtually no difference from her responses. Then why I'd rate this to be the best? Not because of the listed ingredients and claimed benefits, it's based on the following observations:
(1) Nestle Supreme Natural Culture looks like expressed breast milk, not foamy, no film left in the bottle.
(2) The poop color (yellowish) is very similar to that of breast milk too.
From our experience, Enfamil seems the most foamy, Similac is a little grainy, both need to be prepared at least 30 minutes before feeding to let the bubbles settle down or fully desolve. Nestle SNC can be ready in minutes! Truely a high quality product, highly recommend.