When I reached about 40, my hormones suddenly went haywire. I started to get bad adult acne that lasted for months despite all the prescription wash and cream I applied topically. My period would turn irregular for months which rarely happen when I was younger. My doctors said it was not menopause, and they couldn't find anything seriously wrong. After a few years of testing at no avail, I decided to try some herbal suppliment. The first one I decided to take regularly is chasteberry fruit because it is not as intrusive as other herbs. Within a few month of taking Vitex and using the same topical treatments, my acne subsided and finally stopped reappearing all together. My period is more regular and lighter. I read some people who had persistent problem with depression may experience worsen mood swing after taking Vitex. But luckily, I have not experienced much mood change since taking Vitex. I guess every body reacts differently. Since Nature's Way Vitex is the only chasteberry I've ever taken, I can not compare to other brands. But the capsules, though good size, are easy to swallow. I take one daily before bed and never got any upset stomach from it. Manufacture suggests to take a higher dousage for the first 6-8 weeks. But I take only one capsule since day one because I don't take herbal supplement often. I've been taking Vitex for a few months and It's been working great so far.