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I have used Frontline Plus for several years, and it has worked beautifully. I had found it to be a bit less expensive than Advantage and just as effective.
These last two summers, I had noticed a gradual increase in the flea population on my "Dixie". Last summer, I would administer the product and in 3 days, all would be gone. Unfortunately within 3 weeks they were back. This past summer, they would be back "en force" within two.
After consulting with my vet, I was informed that this was not uncommon. As with any "cide", fleas were becoming more and more resistant. She said I could start administering it every two weeks or switch to another brand for once a month protection (the latter became the most cost effective).
This is not to say Frontline isnt good. It is. I rate it highly. Just be advised that whether it be Frontline, Advantage or any of the other products and its variations that are out there.