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I have used Frontline for 14 years (my oldest dog is 15) and never had a problem. I lived in Florida for 7 years and my dog never had fleas. When my oldest dog was very young another dog in the house had fleas but we considered that dog too old to apply a pesticide (Frontline is a pesticide) but we treated my dog, and since they both slept in the same bed, both dogs were rid of fleas! When I worked at PetSmart, I cannot tell you how much of the over the counter flea stuff was returned because it didn't work. Yes, Frontline is expensive, especially if you are treating multiple animals, but for our household, it is all we will use.
One tip: be sure to take off your animal's collar for 24 hours when you apply a treatment. One time our dogs had fleas within a week of treatment when they had NEVER had fleas using Frontline for numerous years before. My vet says sometimes topical flea treatments that go between the shoulder blades get absorbed into the collar and not distributed on the dog.
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