I used this gel after I washed my face, and I used it in the morning and at night. I liked that it didn't dry out my face too much- other acne medications make my skin so dry it becomes scaly. But, Clindamycin was a medication that I could use multiple times per day without negative side effects. Effectiveness My sister and I have both used this medicated gel for acne and it is very effective. You put it on the affected area, and it works to reduce current pimples and also works to prevent future pimples. Ease of Application This gel is extremely easy to apply, and doesn't make a mess. The clear gel leaves no visible trace behind, and does not feel greasy or oily. Wash your face with your regular cleanser, apply to fingers and transfer to face and rub in- it is as easy as that. Convenience This gel is in a pack that is easily closed up so you can take it with you when you travel or are way from home. I found this very convenient to use, however it is an added step to your routine. A 1-sop acne solution would be more ideal, but this is an effective 2nd step in your face washing routine. Side Effects I didn't experience any side effects. Immediacy I did not experience immediate results, I had to use this medicated gel for several weeks when I saw real improvement.