I'd been taking the well known grand-daddy of all anti-depressants for years and it just wasn't working for me anymore. I tried Effexor and experienced negative side effects (anxiety, anger, loss of patience, etc.) and someone suggested I try Celexa. I asked my primary care physician if I could try Celexa and he started me on the medication about two months ago. So far it's worked very well with no negative side effects. I would recommend this product to a friend or family member.