The experience you describe is very sad, but not hopeless. Actually, you both were successful for quite awhile and learned a lot. It can feel like an endless funeral and the loss IS something to grieve! Perhaps starting an effective antidepressant (if can find one) long before Chantix could help your wife and you could both try again. I absolutely disagree with the previous comments about your wife not really wanting to quit and being a self-pitying whatever!! (Clueless people are not helpful unless you're using anger to quit, as I did.) I'm now going thru a time similar to your wife's experience and I KNOW I went into this fully ready, committed and optimistic. I've not smoked for a month and am simply "gutting it out" for as long as I can. Forever would be nice, but that's way too horrible a thought. Today is all I'm aiming for. Tomorrow I'll aim for that day. From past experience, I tailored my own program to me. Also, if I'm not glowing, happy and proud about quitting, well, who says I have to be? I'm glad because I think it's a "good" thing, but I'm not nearly as bubbly about it as perhaps I "should" be. So what? I found a no-fee smoking cessation counselor (trained by Mayo Clinic) to be much more helpful than the Chantix GetQuit website. There are also addiction counselors around if you can find them. Researchers are learning more and more about how addiction affects the brain and sometimes just understanding it helps to fight it. For those of us whose brains matured on nicotine and all the other chemicals, being "ready" and "really wanting" to quit doesn't make it easier. Neither do "bootstraps" or "willpower." Commitment? Maybe that. As in a commitment to accept being as miserable as it takes for as long as it takes until you're not miserable anymore. Each person has his/her own journey. It's obvious how mine's going...(hey, that made me laugh). I wish you both the best on yours!!