I've read a lot of great books but one that I've never shaken was Forfeit by Dick Francis. A thriller/action/mystery/romance, the main character was a sports writer whose wife was so badly paralyzed that she had to use an iron lung to breathe. This caused all sorts of complications and relationship issues, all of which were woven into the story. It was so touching and powerful that the story still comes back to me after 10 years -- it's a real page-turner and I highly recommend it.

--Bob