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I was pleased with the results of Alli at first, but then I started feeling kinda sluggish and not myself. Stopped losing weight, even though I followed the plan to a "t". I didn't verify it with my doctor, but I think it interfered with the absorption of the thyroid hormone I take for hypothyroidism. I stopped taking Alli and about ten days later I started feeling better. I'll lose weight the old fashioned way.